Ibutilide indications include the conversion of acute atrial flutter and atrial fibrillation to normal sinus rhythm (NSR).
Ibutilide has utility as a pretreatment for electro cardioversion. Pretreatment with ibutilide, sotalol, or dofetilide may help conversion to NSR in cases of refractory atrial fibrillation. Ibutilide may also be given post cardioversion to prevent recurrent atrial fibrillation.
Ibutilide administration may be necessary following surgery.
Ibutilide is a potassium channel blocker that prolongs phase 3 of the cardiac action potential, resulting in increased refractoriness of atrial and ventricular myocytes, the atrioventricular node, and the His-Purkinje system.
The cardiac action potential divides into the following five stages:
Phase 0: Rapid Depolarization
During phase 0, fast sodium channels open when the cell reaches the threshold, which results in a rapid depolarization of the myocyte continuing until inactivation gates close, thus abolishing sodium conductance. A time-dependent mechanism mediates the closure of inactivation gates. Reopening of inactivation gates occurs during cell repolarization, specifically upon re-approaching the threshold.
Phase 1: Early repolarization
Potassium channels open, causing an efflux of potassium called the transient outward current (ito). The end of phase 1 is characterized by a balance between calcium influx and potassium efflux, thus leading to the plateau phase.
Phase 2: Plateau
The plateau phase consists of a balance between calcium influx and potassium efflux. The calcium channels are L-type dihydropyridine-receptor channels that inactivate slowly. Drugs that alter the conductance of calcium modulate this phase and belong to Class 4 of the Vaughn-Williams classification system.
During the latter stages of the plateau phase, delayed rectifying potassium channels (iKr) open and allow the myocyte to begin repolarization as the calcium current declines.
Phase 3: Repolarization
In phase 3 of the cardiac action potential, potassium efflux exceeds inward calcium current causing repolarization. When positively charged potassium ions move out of the cell, it restores the negative potential of the cardiac myocyte. Three potassium channels are involved in the repolarization phase. While the cell membrane remains depolarized, iKr and ito are the major contributors to potassium efflux. As the myocyte approaches the threshold, the inwardly rectifying current (iK1) channels open and contribute to repolarization. Although iK1 channels are termed “inwardly rectifying,” potassium efflux occurs due to the electrochemical potential of potassium derived from the cord conductance equation.
Ibutilide is a potassium-blocking agent that primarily exerts its effect on the delayed rectifying potassium channels (iKr). By blocking potassium channels, phase 3 is lengthened, prolonging the QTc interval and increasing the refractoriness of the atrial and ventricular myocytes. When a myocyte is in the absolute refractory period, a subsequent action potential cannot be propagated, thus causing a decrease in the heart rate of patients presenting with tachydysrhythmias.
Ibutilide has also shown to activate a slow, delayed, inward sodium current during the early stages of repolarization. However, blockade of iKr channels is the major contributor to its antiarrhythmic properties.
Phase 4: Resting
Na+/K+ ATPase dominates, phase 4. For every three Na+ ions pumped out of the cell, two K+ ions are pumped in, resulting in a negative resting membrane potential.
A primary active transporter called the calcium ATPase re-sequesters the majority of the intracellular calcium into the sarcoplasmic reticulum. The sarcoplasmic calcium ATPase regulation occurs by an intracellular protein called phospholamban. When phospholamban undergoes phosphorylation via protein kinase A (PKA), the calcium ATPase is active and incorporates cytosolic calcium ions into the sarcoplasmic reticulum. During the next action potential, more calcium is released into the cytosol, thus causing increased contractility. When phospholamban is de-phosphorylated, it inhibits the sarcoplasmic calcium ATPase.
Remaining calcium ions get pumped out of the myocytes by secondary active transport through the Na+/Ca++ exchanger.
It is important to note that the cardiac myocyte Na+/K+ ATPase is inhibited pharmacologically by the cardiac glycosides (digoxin). Inhibition of the Na+/K+ ATPase causes an increase in intracellular Na+ ions and leads to a series of biochemical changes, beginning with the reverse action of membrane-bound Na+/Ca++ exchangers. The change in polarity of Na+/Ca++ exchangers causes an efflux of Na+ and an influx of Ca++ to restore the resting membrane potential in the absence of Na+/K+ ATPase activity. The increased concentration of intracellular calcium is responsible for the positive inotropic properties of digoxin therapy.
Notable ECG Changes
Ibutilide is available as a solution administered intravenously (1 mg/10 mL)
For patients weighing less than 60 kg, the dose is 0.01 mg/kg over 10 minutes.
For patients weighing more than 60 kg, the dose is 1 mg over 10 minutes.
Drug administration may be diluted or undiluted. Discontinue infusion upon resolution of presenting arrhythmia or new-onset ventricular tachycardia. If the arrhythmia does not abate within 10 minutes post-infusion, another dose may be given over 10 minutes.
Renal or Hepatic Impairment: Dosing for renal or hepatic impairment does not need to be adjusted.
Geriatrics: Start at the lower end of the dosing range
Addition of Magnesium Sulfate: Magnesium has been shown to enhance the ability of ibutilide to convert atrial flutter or fibrillation to normal sinus rhythm. Magnesium can also help prevent prolongation of the QT interval, and it sees frequent use in the treatment of torsades de pointes in hemodynamically stable patients.
Class 1C Antiarrhythmics: Ibutilide can be given safely with Class 1C antiarrhythmics since class 1C antiarrhythmics do not affect the QT interval.
Amiodarone: The risk of arrhythmia does not increase when giving ibutilide with amiodarone.
Pharmacokinetics: Conversion to sinus rhythm occurs in less than 90 minutes after the start of infusion. Ibutilide has a half-life of 2 to 12 hours, with an average half-life of 6 hours. It is metabolized extensively by the liver into eight metabolites (1 active). The volume of distribution is approximately 11 L/kg. The majority of the drug is excreted via the urine in the form of inactive metabolites.
According to the Institute for Safe Medication Practices (ISMP), this drug has a heightened risk of causing significant patient harm.
Cardiac Adverse Effects
Extracardiac Adverse Effects
Category X (avoid)
Category D (modify regimen)
Category C (monitor)
Pregnancy Implications: Clinicians may consider the use of ibutilide in pregnancy; however, data regarding its effects are limited. Breastfeeding is not recommended.
Patients require continuous monitoring via ECG for four hours post discontinuation of ibutilide infusion or until the QTc returns to normal (less than 440 msec). If arrhythmia presents, continue monitoring patients for more than four hours. Equipment for the management of potentially fatal arrhythmias should be rapidly available.
According to the Institute for Safe Medication Practices, this medication has a high risk of causing significant patient harm. The entire team, including physicians, physician assistants, nurse practitioners, pharmacists, and nurses, must work together to monitor these patients for potential untoward cardiac and extracardiac events. Given the serious nature of both the conditions for which ibutilide is given, as well as the serious potential for toxicity, the pharmacist should carefully review all orders for ibutilide, as well as perform medication reconciliation. Nursing will be delivering the IV in most cases and can verify the administration duration and dose and monitor closely for any adverse effects. Should there be any concerns, nursing must report these immediately to the healthcare team. Ordering physicians need to rely on nursing and pharmacy to ensure optimal therapy results, creating a collaborative interprofessional team environment. [Level 5]
|||Murray KT, Ibutilide. Circulation. 1998 Feb 10 [PubMed PMID: 9490245]|
|||Oral H,Souza JJ,Michaud GF,Knight BP,Goyal R,Strickberger SA,Morady F, Facilitating transthoracic cardioversion of atrial fibrillation with ibutilide pretreatment. The New England journal of medicine. 1999 Jun 17 [PubMed PMID: 10369847]|
|||VanderLugt JT,Mattioni T,Denker S,Torchiana D,Ahern T,Wakefield LK,Perry KT,Kowey PR, Efficacy and safety of ibutilide fumarate for the conversion of atrial arrhythmias after cardiac surgery. Circulation. 1999 Jul 27 [PubMed PMID: 10421596]|
|||Yang T,Snyders DJ,Roden DM, Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15 [PubMed PMID: 7882490]|
|||Lee KS, Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward Na current in guinea pig ventricular cells. The Journal of pharmacology and experimental therapeutics. 1992 Jul [PubMed PMID: 1320693]|
|||Whayne TF Jr, Clinical Use of Digitalis: A State of the Art Review. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2018 Jul 31 [PubMed PMID: 30066080]|
|||Patsilinakos S,Christou A,Kafkas N,Nikolaou N,Antonatos D,Katsanos S,Spanodimos S,Babalis D, Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent. The American journal of cardiology. 2010 Sep 1 [PubMed PMID: 20723644]|
|||Caron MF,Kluger J,Tsikouris JP,Ritvo A,Kalus JS,White CM, Effects of intravenous magnesium sulfate on the QT interval in patients receiving ibutilide. Pharmacotherapy. 2003 Mar [PubMed PMID: 12627926]|
|||Hongo RH,Themistoclakis S,Raviele A,Bonso A,Rossillo A,Glatter KA,Yang Y,Scheinman MM, Use of ibutilide in cardioversion of patients with atrial fibrillation or atrial flutter treated with class IC agents. Journal of the American College of Cardiology. 2004 Aug 18 [PubMed PMID: 15312873]|
|||Glatter K,Yang Y,Chatterjee K,Modin G,Cheng J,Kayser S,Scheinman MM, Chemical cardioversion of atrial fibrillation or flutter with ibutilide in patients receiving amiodarone therapy. Circulation. 2001 Jan 16 [PubMed PMID: 11208685]|
|||Regitz-Zagrosek V,Blomstrom Lundqvist C,Borghi C,Cifkova R,Ferreira R,Foidart JM,Gibbs JS,Gohlke-Baerwolf C,Gorenek B,Iung B,Kirby M,Maas AH,Morais J,Nihoyannopoulos P,Pieper PG,Presbitero P,Roos-Hesselink JW,Schaufelberger M,Seeland U,Torracca L, ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). European heart journal. 2011 Dec [PubMed PMID: 21873418]|